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Singh, Jitendra Kumar
- Di (2-Ethylhexyl) Phthalate Induced Toxicological Effects on Reproductive System of Female Mice Mus-Musculus
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Authors
Affiliations
1 Department of Botany and Biotechnology, Thakur Prasad Singh (T.P.S. College) College, Patliputra University, Patna – 800020, Bihar, IN
2 S. S. Hospital and Research Institute, Patna – 800020, Bihar, IN
1 Department of Botany and Biotechnology, Thakur Prasad Singh (T.P.S. College) College, Patliputra University, Patna – 800020, Bihar, IN
2 S. S. Hospital and Research Institute, Patna – 800020, Bihar, IN
Source
Journal of Ecophysiology and Occupational Health, Vol 19, No 1-2 (2019), Pagination: 71-75Abstract
Di-(2-ethylhexyl) phthalate is an environmental endocrine disruptor and reproductive toxicant. It impairs the structural and functional aspects of female reproduction and also alters the molecular, endocrinological, cytological and biochemical aspects, causing ovarian cycle irregularity and infertility. DEHP was orally administered at lower dose of 10 mg/kg bwt to mice for six to twenty four weeks period which resulted in alterations of the serum levels of hormones estrogen and progesterone. The altered values of hormones were found to be statistically very significant (P<0.001). The present study indicated the adverse effects of exposure of DEHP on female reproductive health.
Keywords
Corn Oil Reproductive System, DEHP, Hormones, Infertility.Full Text
References
- Wittassek M, Weissmuller GA, Koch HM, Eckard R, Dobler L, Muller J, Angerer J, Schluter C. Internal phthalate exposure over the last two decades- aretrospective human biomonitoring study. Int J Hyg Environ Health. 2007; 210:319–33. https://doi.org/10.1016/j.ijheh.2007.01.037 PMid:17400024
- JAColacino TR, Harris A, Schecter. Dietary intake is associated with phthalate body burden in a nationally representative sample, Environ. Health Perspect. 2010; 118:998–1003. https://doi.org/10.1289/ehp.0901712 PMid:20392686 PMCid:PMC2920922
- Latini G, Avery GB. Materials degradation in endotracheal tubes: A potential contributor to bronchopulmonary dysplasia. Acta Pediatr. 1999; 88:1174–5. https://doi.org/10.1111/j.1651-2227.1999.tb01011.x
- Latini G. The potential hazards of exposure to di-(2-ethylhexyl)phthalate in babies a review. Biol. Neonate. 2000; 78:269–76. https://doi.org/10.1159/000014278 PMid:11093005
- Tickner JA, Schettler T, Guidotti T, McCally M, Rossi M. Overview of patient health risks posed by the use of di-2-ethylhexyl phthalate (DEHP) in PVC medical devices. Am J Ind Med. 2001; 39:100–11. https://doi.org/10.1002/10970274(200101)39:1<100::AID-AJIM10>3.0.CO;2-Q
- US food and drug administration center for devices and radiological health. Safety assessment of di(2-ethylhexyl)phthalate (DEHP) released from PVC medical devices. Available from: http://www.fda.gov/cdrh/ost/dehp-pvc.pdf
- Health Canada Expert Advisory Panel on DEHP Final Report 2002 January 11.
- Heindel JJ, Gulati DK, Mounce RC, Susan RR, Lamb JCIV. Reproductive toxicity of three phthalic acid esters in a continuous breeding protocol. Fundam Appl Toxicol. 1989; 12:508–18. https://doi.org/10.1016/0272-0590(89)90024-9
- Latini G, Del Vecchio A, Massaro M, Verrotti A, De Felice C. In utero exposure to phthalates and fetal development. Curr Med Chem. 2006; 13:2527–34. https://doi.org/10.2174/092986706778201666 PMid:17017909
- Latini G, Del Vecchio A, Massaro M, Verrotti A, De Felice C. In utero exposure to phthalates and fetal development. Curr Med Chem. 2006; 13:2527–34. https://doi.org/10.2174/092986706778201666 PMid:17017909
- Adibi JJ, Perera FP, Jedrychowski W, Camann DE, Barr D, et al. Prenatal exposures to phthalates among women in New York City and Krakow, Poland. Environ Health Perspect. 2003; 111:1719–22. https://doi.org/10.1289/ehp.6235 PMid:14594621 PMCid:PMC1241713
- Latini G. Monitoring phthalate exposure in humans. Clinchim Acta. 2005; 361:20–7. https://doi.org/10.1016/j.cccn.2005.05.003 PMid:16004980
- OEHHA. No, significant risk level (NSRL) for the proposition 65 carcinogen Di(2-Ethylexyl) Phthalate, California Environmental Protection Agency; 2001.
- Ito Y, Yamanoshita O, Asaeda N, Tagawa Y, Lee CH Aoyama T, Ichihara G, Furuhashi K, Kamijima M, Gonzalez FJ, Nakajima T. Di(2-ethylhexyl)phthalate induces hepatic tumorigenesis through a peroxisome proliferator-activated receptor alpha-independent pathway. Journal of Occupational Health. 2007; 49(3):172–82. https://doi.org/10.1539/joh.49.172 PMid:17575397
- Pocar P, Fiandanese N, Secchi C, Berrini A, Fischer B, Schmidt JS, Schaedlich K, Borromeo V. Exposure to di(2-ethyl-hexyl) phthalate (DEHP) in utero and during lactation causes longterm pituitary-gonadal axis disruption in male and female mouse offspring. Endocrinology. 2012; 153(2):937-48. https://doi.org/10.1210/en.2011-1450 PMid:22147016
- Takai R, Hayashi S, Kiyokawa J, et al. Collaborative work on evaluation of ovarian toxicity. 10) Two- or four-week repeated dose studies and fertility study of di-(2-ethylhexyl) phthalate (DEHP) in female rats. J Toxicol Sci 2009; 34(Suppl 1):SP111–9. https:// doi.org/10.2131/jts.34.S111 PMid:19265277
- Ma M, Kondo T, Ban S. Exposure of prepubertal female rats to inhaled di(2 ethylhexyl)phthalate affects the onset of puberty and postpubertal reproductive functions. Toxicol Sci. 2006; 93(1):164– 71. https://doi.org/10.1093/toxsci/kfl036 PMid:16763069
- Svechnikova I, Svechnikov K, Söder O. The influence of di-(2-ethylhexyl) phthalate on steroidogenesis by the ovarian granulosa cells of immature female rats. J Endocrinol. 2007; 194(3):603–9. https://doi.org/10.1677/JOE-07-0238 PMid:17761899
- Pocar P, Fiandanese N, Secchi C, Berrini A, Fischer B, Schmidt JS, Schaedlich K, Borromeo V. Exposure to di(2-ethyl-hexyl) phthalate (DEHP) in utero and during lactation causes longterm pituitary-gonadal axis disruption in male and female mouse offspring. Endocrinology. 2012; 153(2):937–48. https:// doi.org/10.1210/en.2011-1450 PMid:22147016
- Davis BJ, Maronpot RR, Heindel JJ. Di-(2-ethylhexyl) phthalate suppresses estradiol and ovulation in cycling rats. Toxicol Appl Pharmacol. 1994; 128(2):216–23. https://doi.org/10.1006/ taap.1994.1200 PMid:7940536
- Lovekamp Swan T, Davis BJ. Mechanisms of phthalate ester toxicity in the female reproductive system. Environ Health Perspect. 2003; 111(2):139–45. https://doi.org/10.1289/ehp.5658 PMid:12573895 PMCid:PMC1241340
- Högberg J, Hanberg A, Berglund M, et al. Phthalate diesters and their metabolites in human breast milk, blood or serum, and urine as biomarkers of exposure in vulnerable populations. Environ Health Perspect. 2008; 116(3):334–9. https://doi.org/10.1289/ehp.10788 PMid:18335100 PMCid:PMC2265037
- Genuis SJ. Human elimination of phthalate compounds: blood, urine, and sweat (BUS) study. Scientific World J. 2012; 2012:615068. https://doi.org/10.1100/2012/615068 PMid:23213291 PMCid:PMC3504417
- Jobling S, Reynolds T, White R, Parker MG, Sumpter JP. A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic. Environ Health Perspect. 1995; 103:582–7. https://doi.org/10.1289/ehp.95103582 PMid:7556011 PMCid:PMC1519124
- Harris CA, Henttu P, Parker MG, Sumpter JP. The estrogenic activity of phthalate esters in vitro. Environ Health Perspect. 1997; 105:802–811. https://doi.org/10.1289/ehp.97105802 PMid:9347895 PMCid:PMC1470189
- Maria De Falco, Maurizio Forteand Vincenza Laforgia. Estrogenic and anti androgenic endocrine disrupting chemicals and their impact on the male reproductive system. Environmental Toxicology. 2015; 3.
- Bhattacharya P, Keating AF. Impact of environmental exposures on ovarian function and role of xenobiotic metabolism during ovotoxicity. Toxicol Appl Pharmacol. 2012; 261(3):227–35. https://doi.org/10.1016/j.taap.2012.04.009 PMid:22531813 PMCid:PMC3359424
- Craig ZR, Wang W, Flaws JA. Endocrine-disrupting chemicals in ovarian function: effects on steroidogenesis, metabolism and nuclear receptor signaling. Reproduction. 2011; 142(5): 633–46. https://doi.org/10.1530/REP-11-0136 PMid:21862696
- Pocar P, Fiandanese N, Secchi C, et al. Exposure to di(2-ethylhexyl) phthalate (DEHP) in utero and during lactation causes long-term pituitary-gonadal axis disruption in male and female mouse offspring. Endocrinology. 2012; 153(2):937–48. https://doi.org/10.1210/en.2011-1450 PMid:22147016
- Zhang XF, Zhang LJ, Li L, et al. Diethylhexyl phthalate exposure impairs follicular development and affects oocyte maturation in the mouse. Environ Mol Mutagen. 2013; 54(5):354–61. https://doi.org/10.1002/em.21776 PMid:23625783
- Agarwal DK, Lawrence WH, Turner JE, and Autian, J. Effects of parenteral di-(2-ethylhexyl) phthalate (DEHP) on gonadal biochemistry pathology and reproductive performance of mice. J Toxicol Environ Health. 1989; 26:39–59. https://doi.org/10.1080/15287398909531232 PMid:2913333